2026 Salary — South Carolina
Updated April 29, 2026
Nurse Practitioner Salary in South Carolina: $118K Median
Nurse Practitioners in South Carolina earn between $87K and $161K per year.
That's -8% below the US national median.
Quick Answer
As of April 2026, the median Nurse Practitioner salary in South Carolina is $118,211 per year — -8% below the US national median of $128,490. Salaries range from $87,400 (entry, 25th percentile) to $161,000 (90th percentile). South Carolina's cost-of-living index is 95. State income tax applies.
Median
$118,211
+560.0% YoY
Entry
$92,000
Experienced
$142,600
Top 10%
$161,000
About Nurse Practitioners in South Carolina
NPs are advanced practice registered nurses who diagnose conditions, prescribe medications, and provide primary or specialty care.
Hot 2026 Skills
Telehealth NPMental health (PMHNP)Pediatric NPGeriatric NPFull practice authority states
ATS Keywords
NP certificationpatient careEHR (Epic)primary carepediatricmental healthtelehealth
How to Negotiate Your Nurse Practitioner Salary in South Carolina
Walk-away anchor: $107,465.
Leverage Points
- Specialty certifications (CCRN, OCS, BCPS, FNP) command 8-15% premiums
- Compact license / multi-state authority and willingness to float between units
- Night, weekend, and holiday shift differentials add up to $10K-$25K annually
- Critical-shortage specialties (ICU, ER, NICU, oncology) have the most leverage
Negotiate Beyond Base
Sign-on bonus ($10K-$30K, often $50K+ for hard-to-fill roles)Tuition reimbursement and certification stipendsLoan repayment programs (especially federal/HRSA-eligible)Shift differentials (nights +15%, weekends +10%)Relocation package and housing stipend
Nurse Practitioner Salary FAQ — South Carolina
What is the average Nurse Practitioner salary in South Carolina?
The average Nurse Practitioner salary in South Carolina is $118,211 per year as of April 2026. Salaries range from $87,400 (entry, 25th percentile) up to $161,000 (90th percentile). State income tax applies.
How does Nurse Practitioner pay in South Carolina compare to the US average?
Nurse Practitioners in South Carolina earn approximately 8% less than the US national median ($128,490 nationally vs $118,211 in South Carolina). South Carolina's cost-of-living index of 95 is close to the national average.
Did Nurse Practitioner salaries in South Carolina increase in 2026?
Yes — Nurse Practitioner salaries in South Carolina grew approximately 560.0% year-over-year, from $17,911 in 2025 to $118,211 in 2026. This reflects the broader Healthcare sector's wage growth, driven by Telehealth NP and Mental health (PMHNP) demand.
Which South Carolina cities pay Nurse Practitioners the most?
South Carolina has no major metros in our database — fallback to the closest tracked city for detailed breakdowns.
What's the job outlook for Nurse Practitioners in South Carolina?
NP roles growing 38% through 2034 — among fastest-growing US occupations. Full practice authority in 27 states drives demand. South Carolina's top industries include Manufacturing (BMW, Boeing), Tourism, Aerospace, and the state's unemployment rate is 3.5% — a tight labor market favoring candidates.
Does South Carolina have state income tax?
Yes, South Carolina has state income tax. This affects take-home pay — at $118,211, expect 4-7% effective state tax depending on filing status. See city pages for detailed take-home calculations.
What skills are most in demand for Nurse Practitioners in 2026?
Hottest 2026 skills: Telehealth NP, Mental health (PMHNP), Pediatric NP, Geriatric NP, Full practice authority states. ATS systems specifically scan for these. Adding them to your resume — naturally and in context — improves your match rate with South Carolina employers.
How can I increase my Nurse Practitioner salary in South Carolina?
Given the current shortage in this specialty and my certifications, I'm looking for $X base plus shift differential and a sign-on bonus. What flexibility do you have on those line items? Beyond base, negotiate: Sign-on bonus ($10K-$30K, often $50K+ for hard-to-fill roles), Tuition reimbursement and certification stipends, Loan repayment programs (especially federal/HRSA-eligible), Shift differentials (nights +15%, weekends +10%). Walk-away anchor for South Carolina: $107,465.
Methodology
South Carolina Nurse Practitioner salary is the BLS national median ($128,490) adjusted by South Carolina's state multiplier (0.92×). YoY rate from BLS Employment Cost Index. Last reviewed April 29, 2026.
Nurse Practitioner Salary in Other States
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